Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507119 | 1.00 | DGAT1 (0.34) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL18547508 | 0.83 | DGAT1 (0.38) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL23022131 | 0.83 | DGAT1 (0.35) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL23022193 | 0.78 | DGAT1 (0.38) | DGAT1 | |
| SCHEMBL2112413 | 0.77 | DGAT1 (0.39) | DGAT1BRD4CREBBP | |
| SCHEMBL21632543 | 0.77 | MAPT (0.35) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL16477538 | 0.76 | PDE10A (0.35) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL31554497 | 0.76 | DGAT1 (0.38) | DGAT1NPC1MAPTBRD4CREBBP | |
| SCHEMBL20893945 | 0.75 | ALDH1A1 (0.36) | DGAT1FLT4KDR | |
| SCHEMBL22761902 | 0.75 | DGAT1 (0.35) | DGAT1NPC1MAPTBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |