Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355302 | 0.91 | MAPT (0.55) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2304830 | 0.86 | ALDH1A1 (0.58) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2303642 | 0.85 | ADORA3 (0.55) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2357175 | 0.83 | ADORA3 (0.53) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2302641 | 0.81 | MEN1 (0.66) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2363666 | 0.81 | ADORA3 (0.50) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2301452 | 0.81 | ADORA3 (0.51) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2300888 | 0.80 | ADORA3 (0.62) | SMN1; SMN2MAPTHPGDKDM4ELMNA | |
| SCHEMBL2300926 | 0.80 | ADORA3 (0.59) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL2301455 | 0.80 | ADORA3 (0.51) | SMN1; SMN2MAPTHPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350311-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010056506-A1 | DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |