Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 2/20 | 0.38 |
| ▸ | ATP4B | P51164 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24857399 | 0.81 | CTSS (0.37) | HDAC8TP53MAPTKDM4EHPGD | |
| SCHEMBL23029849 | 0.80 | HDAC8 (0.43) | HDAC8TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL23030042 | 0.79 | HDAC8 (0.42) | HDAC8TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL23030111 | 0.79 | HDAC8 (0.45) | HDAC8TP53MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL17371704 | 0.76 | HDAC8 (0.49) | HDAC8TP53MAPTALDH1A1HPGD | |
| SCHEMBL24342050 | 0.75 | HDAC8 (0.42) | HDAC8TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL31538786 | 0.73 | GPR84 (0.57) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL18205724 | 0.72 | KDM4E (0.50) | HDAC8TP53MAPTKDM4EALDH1A1 | |
| Bromide SCHEMBL31538776 | 0.72 | GPR84 (0.56) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL13556610 | 0.72 | HDAC8 (0.43) | HDAC8TP53MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4019521-A1 | AZAHETEROARYL COMPOUND AND APPLICATION THEREOF | Blueray Therapeutics (Shanghai) Co., Ltd (CN) | 2022-06-29 | — | — | EP | disclosed |
| WO-2021032004-A9 | AZAHETEROARYL COMPOUND AND APPLICATION THEREOF | 上海青煜医药科技有限公司 | 2021-03-25 | — | — | WO | disclosed |
| WO-2021032004-A1 | AZAHETEROARYL COMPOUND AND APPLICATION THEREOF | 上海青煜医药科技有限公司 | 2021-02-25 | — | — | WO | disclosed |