Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891742 | 0.72 | MAP2K4 (0.48) | MPLALOX5APFEN1POLB | |
| SCHEMBL1891905 | 0.72 | HSD11B1 (0.50) | MPLPDE2AHSD11B1CYP11B1CYP11B2 | |
| SCHEMBL2390447 | 0.69 | ALDH1A1 (0.39) | MPLHSD11B1ALOX5AP | |
| SCHEMBL1893971 | 0.69 | FEN1 (0.44) | MPLHSD11B1ALOX5APFEN1 | |
| SCHEMBL1885446 | 0.67 | MEN1 (0.47) | MPLCRHR1ALOX5APFEN1 | |
| SCHEMBL2386650 | 0.67 | MPL (0.41) | MPLPDE2AHSD11B1ALOX5APFEN1 | |
| SCHEMBL2386527 | 0.67 | ADORA2A (0.43) | MPLHSD11B1ALOX5APFEN1MAPT | |
| SCHEMBL2307176 | 0.66 | MPL (0.41) | MPLHSD11B1ALOX5APFEN1POLB | |
| SCHEMBL2388021 | 0.65 | MPL (0.40) | MPLHSD11B1ALOX5APFEN1POLB | |
| SCHEMBL2390925 | 0.65 | HSD11B1 (0.43) | MPLHSD11B1ALOX5APFEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350023-A1 | 6-PHENYL-PYRIMIDIN-4-YL-(PHENYLAMINE OR PHENOXY) DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch A/S (DK) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010040826-A1 | 6-PHENYL-PYRIMIDIN-4-YL-(PHENYLAMINE OR PHENOXY) DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-04-15 | — | — | WO | disclosed |