Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29978338 | 1.00 | NR1I2 (0.46) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL23043609 | 0.84 | KDM4E (0.50) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL29978692 | 0.84 | KDM4E (0.50) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL23043589 | 0.81 | GFER (0.53) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL29978661 | 0.81 | GFER (0.53) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL19314110 | 0.75 | FFAR1 (0.51) | ARMAPTHPGDKDM4ENPSR1 | |
| SCHEMBL2108563 | 0.72 | AR (0.49) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL30667261 | 0.71 | S100B (0.61) | MAPTKDM4ENPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6720035 | 0.71 | ALDH1A1 (0.43) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL359524 | 0.70 | KDM4E (0.50) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041866-A1 | SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |