Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 6/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29707038 | 0.88 | GAA (0.42) | KDM4EHSD17B10ALDH1A1HPGDGLA | |
| SCHEMBL23051557 | 0.88 | GAA (0.42) | KDM4EHSD17B10ALDH1A1HPGDGLA | |
| SCHEMBL23043891 | 0.73 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1HPGDXDH | |
| SCHEMBL8586090 | 0.70 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1HPGDXDH | |
| SCHEMBL15357877 | 0.69 | CYP46A1 (0.40) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL30087109 | 0.69 | HPGDS (0.30) | — | |
| SCHEMBL31219573 | 0.68 | NNMT (0.31) | — | |
| SCHEMBL31220060 | 0.68 | KDM4E (0.33) | KDM4EGAA | |
| SCHEMBL9091041 | 0.67 | — | — | |
| SCHEMBL2160545 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021580-A1 | CEREBLON E3 LIGASE INHIBITORS | The Regents Of The University Of Michigan (US) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021041664-A1 | CEREBLON E3 LIGASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |