Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048583 | 0.84 | WNT1 (0.41) | WNT1GSK3BDYRK1AHRH4HCRTR2 | |
| SCHEMBL19546938 | 0.84 | WNT1 (0.39) | WNT1GSK3BDYRK1AHRH4HCRTR2 | |
| SCHEMBL23916367 | 0.74 | HRH4 (0.36) | DYRK1AHRH4KDM2B | |
| SCHEMBL23048678 | 0.73 | POLB (0.40) | WNT1GSK3BDYRK1A | |
| SCHEMBL20951081 | 0.72 | KDM2B (0.54) | WNT1GSK3BDYRK1ADDB1CRBN | |
| SCHEMBL8302529 | 0.71 | EHMT2 (0.42) | WNT1GSK3BDYRK1AHCRTR2DDB1 | |
| SCHEMBL23048665 | 0.71 | HRH4 (0.52) | HRH4HTR3A | |
| SCHEMBL20951194 | 0.68 | WNT1 (0.49) | WNT1GSK3BDYRK1AHCRTR2DDB1 | |
| SCHEMBL8302411 | 0.66 | TLR9 (0.37) | WNT1GSK3BDYRK1AHRH4LRRK2 | |
| SCHEMBL23048624 | 0.63 | DYRK1A (0.39) | WNT1DYRK1AHRH4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |