Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 7/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19546880 | 0.84 | HTR6 (0.39) | HRH4HRH3HTR6KDM2BACHE | |
| SCHEMBL23048639 | 0.74 | WNT1 (0.38) | HRH4KDM2BDYRK1A | |
| SCHEMBL23048678 | 0.73 | POLB (0.40) | CLK2DYRK1A | |
| SCHEMBL8302404 | 0.71 | KDM4E (0.50) | HRH4HRH3HTR6ACHE | |
| SCHEMBL23048665 | 0.71 | HRH4 (0.52) | HRH4HRH3CLK4 | |
| SCHEMBL19547077 | 0.70 | HRH3 (0.41) | HRH3DRD2 | |
| SCHEMBL16293110 | 0.69 | KDM2B (0.38) | KDM2B | |
| SCHEMBL30646560 | 0.65 | HRH3 (0.43) | HRH4HRH3HTR6ACHE | |
| SCHEMBL23617940 | 0.65 | NOS3 (0.49) | HRH4HRH3KDM2BACHE | |
| SCHEMBL8899868 | 0.65 | NR3C1 (0.36) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |