Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 10/20 | 0.39 |
| ▸ | HTR2C | P28335 | 10/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19546613 | 0.86 | POLB (0.42) | WNT1GSK3BDYRK1APOLBMEN1 | |
| SCHEMBL23048678 | 0.84 | POLB (0.40) | WNT1GSK3BDYRK1APOLBMEN1 | |
| SCHEMBL20951950 | 0.77 | KDM2B (0.53) | WNT1GSK3BDYRK1APOLBMEN1 | |
| SCHEMBL23048644 | 0.76 | WNT1 (0.47) | WNT1GSK3BDYRK1APOLBMEN1 | |
| SCHEMBL29119703 | 0.76 | HCRTR2 (0.46) | WNT1GSK3BDYRK1APOLBMEN1 | |
| SCHEMBL8630443 | 0.74 | ALDH1A1 (0.47) | PROKR1HTR2AHTR2CL3MBTL1ALDH1A1 | |
| SCHEMBL4778442 | 0.72 | CYP2A6 (0.42) | DYRK1AMEN1KMT2APROKR1TSHR | |
| SCHEMBL31601837 | 0.72 | CYP2A6 (0.42) | DYRK1AMEN1KMT2APROKR1TSHR | |
| SCHEMBL23048797 | 0.71 | OPRD1 (0.46) | WNT1GSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL23048583 | 0.71 | WNT1 (0.41) | WNT1GSK3BDYRK1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |