⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765361 | 0.79 | — | — | |
| SCHEMBL12544684 | 0.79 | — | — | |
| SCHEMBL9468728 | 0.77 | CYP2D6 (0.47) | — | |
| SCHEMBL9468653 | 0.77 | CYP2D6 (0.47) | — | |
| SCHEMBL642855 | 0.76 | CYP2D6 (0.46) | — | |
| SCHEMBL10755241 | 0.76 | CYP2D6 (0.46) | — | |
| SCHEMBL22329028 | 0.76 | CYP2D6 (0.46) | — | |
| SCHEMBL2305984 | 0.76 | CYP2D6 (0.46) | — | |
| SCHEMBL241537 | 0.75 | ALDH1A1 (0.46) | — | |
| SCHEMBL10275655 | 0.75 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350311-B1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | MADRIGAL PHARMACEUTICALS INC (US) | 2013-12-25 | — | — | EP | claimed |
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | claimed |
| EP-2350311-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2011-08-03 | — | — | EP | claimed |
| WO-2010056506-A1 | DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | claimed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | claimed |
| CN-109810073-B | 4-arylthiazole derivatives and pharmaceutical compositions thereof | 南京海辰药业股份有限公司 | 2023-01-06 | — | — | CN | disclosed |
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| EP-2350311-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2319850-A1 | OPTICALLY ACTIVE -AMINO ACID INTO WHICH BSH IS INTRODUCED AND METHOD FOR SYNTHESIZING THE SAME | Stella Pharma Corporation (JP) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010056506-A1 | DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
| EP-0320136-B1 | Imidazoquinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-07-27 | — | — | EP | disclosed |
| EP-0274009-A1 | Oxadiazolylacetonitriles, their preparation and use | NOVO NORDISK A/S (DK) | 1988-07-13 | — | — | EP | disclosed |
| US-4727153-A | NERVOUS SYSTEM DISORDERS | A/S FERROSAN (DK) | 1988-02-23 | — | — | US | disclosed |
| EP-0241682-A2 | Novel benzodiazepine derivatives and their preparation and use | NOVO NORDISK A/S (DK) | 1987-10-21 | — | — | EP | disclosed |
| EP-0226282-A2 | Heterocyclic compounds and their preparation and use | A/S FERROSAN (DK) | 1987-06-24 | — | — | EP | disclosed |
| EP-0225013-A1 | Heterocyclic compounds and their preparation and use | A/S FERROSAN (DK) | 1987-06-10 | — | — | EP | disclosed |
| US-4670433-A | CARDIOVASCULAR DISORDERS | A/S FERROSAN (DK) | 1987-06-02 | — | — | US | disclosed |
| EP-0220845-A1 | Heterocyclic compounds and their preparation and use | A/S FERROSAN (DK) | 1987-05-06 | — | — | EP | disclosed |
| EP-0197282-A1 | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds | A/S FERROSAN (DK) | 1986-10-15 | — | — | EP | disclosed |