Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8781074 | 0.88 | TYR (0.43) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL8781072 | 0.83 | GAA (0.41) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL4576433 | 0.80 | PRKCI (0.44) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL398586 | 0.78 | GAA (0.46) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL5377939 | 0.78 | PRKCI (0.42) | GAAMAPTHTTTSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL8667386 | 0.77 | GAA (0.48) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL7747248 | 0.77 | ALDH1A1 (0.50) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL18657158 | 0.77 | TAAR1 (0.36) | GAAMAPTHTTTSHRPRKCI | |
| SCHEMBL15835001 | 0.77 | PRKCI (0.41) | GAAMAPTHTTTSHRMAPK1 | |
| SCHEMBL13886946 | 0.77 | PRKCI (0.41) | GAAMAPTHTTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313385-B1 | AZIRIDINE CONTAINING DNA ALKYLATING AGENTS | THRESHOLD PHARMACEUTICALS INC (US) | 2021-03-03 | — | — | EP | disclosed |