Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8667386 | 0.98 | GAA (0.48) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL10492538 | 0.87 | TYR (0.46) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL10890416 | 0.85 | CASP1 (0.46) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL9819079 | 0.85 | TYR (0.46) | GAAMAPTCASP1HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11214753 | 0.85 | MAPT (0.46) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL4576433 | 0.84 | PRKCI (0.44) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL7568808 | 0.84 | MAPT (0.49) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL10635917 | 0.84 | MAPT (0.49) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL9025493 | 0.84 | MAPT (0.49) | GAAMAPTCASP1HTTALDH1A1 | |
| SCHEMBL10496381 | 0.84 | MAPT (0.49) | GAAMAPTCASP1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4760185-A | Process for the ortho-alkylation of optionally alkyl-substituted m-phenylenediamines | BAYER AKTIENGESELLSCHAFT (DE) | 1988-07-26 | — | — | US | claimed |
| US-4324553-A | OXIDATION COLOR DYES | L'OREAL (FR) | 1982-04-13 | — | — | US | claimed |
| CN-107501099-B | Modulators of ATP-binding cassette transporters | 沃泰克斯药物股份有限公司 | 2021-03-19 | — | — | CN | disclosed |
| EP-3705477-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| CN-110476243-A | The manufacturing method of electronic circuit protection materials, electronic circuit protection materials sealing material, encapsulating method and semiconductor device | HITACHI CHEMICAL CO LTD | 2019-11-19 | — | — | CN | disclosed |
| US-10413499-B2 | Oxidative hair treatment with post-treatment for improving fastness to washing | HENKEL AG & CO. KGAA (DE) | 2019-09-17 | — | — | US | disclosed |
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-16 | — | — | US | disclosed |
| US-4225492-A | Water-soluble disazo dyestuffs, prepared from unsymmetrical heterocyclic diamines | CASSELLA AKTIENGESELLSCHAFT (DE) | 1980-09-30 | — | — | US | disclosed |
| US-4195151-A | PRODUCTION OF POLYURETHANE ELASTOMERS | UNION CARBIDE CORPORATION (US) | 1980-03-25 | — | — | US | disclosed |
| EP-0008307-A1 | Polyurethane foams prepared from condensation products of amines, epihalohydrins and alkylene oxides | BASF WYANDOTTE CORPORATION (US) | 1980-03-05 | — | — | EP | disclosed |
| US-4144231-A | Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component | CASSELLA AKTIENGESELLSCHAFT (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4144230-A | Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component | CASSELLA AKTIENGESELLSCHAFT (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4143033-A | WATER-SOLUBLE DISAZO DYESTUFFS CONTAINING A 2-PHENYL-BENZIMIDAZOLYL,-BENZOXAZOLYL OR-BENZTHIAZOLYL MIDDLE COMPONENT | CASSELLA AKTIENGESELLSCHAFT (DE) | 1979-03-06 | — | — | US | disclosed |
| US-4137228-A | HIGH TINCTORIAL STRENGTH, COLORFASTNESS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1979-01-30 | — | — | US | disclosed |
| US-4133780-A | Polyurethane foams prepared from condensation products of amines, epihalohydrins and alkylene oxides | BASF WYANDOTTE CORPORATION (US) | 1979-01-09 | — | — | US | disclosed |
| US-4107106-A | Phenol-aldehyde-amine resin/glycol curatives for energy absorbing polyurethanes | UNION CARBIDE CORPORATION (US) | 1978-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | GAA 454/4885MAPT 4269/4885CASP1 4480/4885 |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | GAA 454/4885MAPT 4269/4885CASP1 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.