Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21646370 | 0.86 | ABL1 (0.38) | TRPM5ABL1NPC1RAB9ATDP1 | |
| SCHEMBL8306127 | 0.80 | TRPM5 (0.50) | TRPM5SYKNPC1RAB9ALMNA | |
| SCHEMBL31611304 | 0.80 | TRPM5 (0.50) | TRPM5SYKNPC1RAB9ALMNA | |
| SCHEMBL9342439 | 0.77 | ROCK2 (0.51) | TRPM5NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL13996498 | 0.76 | TRPM5 (0.57) | TRPM5SYKNPC1RAB9ARECQL | |
| SCHEMBL13993989 | 0.76 | TRPM5 (0.47) | TRPM5SYKNPC1RAB9AALDH1A1 | |
| SCHEMBL8226765 | 0.73 | NPC1 (0.41) | TRPM5NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL1999840 | 0.72 | TRPM5 (0.44) | TRPM5SYKNPC1RAB9AALDH1A1 | |
| SCHEMBL23055244 | 0.72 | TRPM8 (0.34) | TRPM5ABL1TDP1TRPM8 | |
| SCHEMBL1999837 | 0.72 | TRPM5 (0.44) | TRPM5SYKNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021039961-A1 | RING-FUSED PYRAZOLE DERIVATIVE | 大日本住友製薬株式会社 | 2021-03-04 | — | — | WO | disclosed |