SCHEMBL23055432 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	RET	P07949	6/20	0.36

▸	CKS1B	P61024	4/20	0.35

▸	SKP1	P63208	4/20	0.35

▸	SKP2	Q13309	4/20	0.35

▸	F2	P00734	1/20	0.34

▸	F10	P00742	1/20	0.34

▸	F7	P08709	1/20	0.34

▸	F3	P13726	1/20	0.34

▸	PTPN11	Q06124	4/20	0.34

▸	PGK1	P00558	1/20	0.34

▸	CNR1	P21554	1/20	0.33

▸	CCNT1	O60563	1/20	0.32

▸	PIK3R1	P27986	2/20	0.32

▸	PIK3CA	P42336	2/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24784245	0.83	RET (0.34)	RETCKS1BSKP1SKP2F2
SCHEMBL23055428	0.69	KDM4E (0.36)	RETCKS1BSKP1SKP2
SCHEMBL23639175	0.69	CKS1B (0.40)	CKS1BSKP1SKP2
SCHEMBL23639161	0.69	CKS1B (0.35)	RETCKS1BSKP1SKP2PTPN11
SCHEMBL20399737	0.67	RET (0.41)	RETCNR1PIK3R1PIK3CA
SCHEMBL30561170	0.67	RET (0.41)	RETCNR1PIK3R1PIK3CA
SCHEMBL23509006	0.65	RET (0.41)	RETCNR1PIK3R1PIK3CA
SCHEMBL30671539	0.63	CKS1B (0.42)	RETCKS1BSKP1SKP2
SCHEMBL29118287	0.63	CKS1B (0.42)	RETCKS1BSKP1SKP2
SCHEMBL29118288	0.63	CKS1B (0.38)	RETCKS1BSKP1SKP2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021039961-A1	RING-FUSED PYRAZOLE DERIVATIVE	大日本住友製薬株式会社	2021-03-04	—	—	WO	disclosed