SCHEMBL23055428

SCHEMBL23055428

CC1(C)CCN(c2cnc3cnn(CC(=O)OC(C)(C)C)c3n2)CC1

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CKS1B P61024 4/20 0.36
SKP1 P63208 4/20 0.36
SKP2 Q13309 4/20 0.36
GRIN2B Q13224 12/20 0.36
RET P07949 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23639174 0.85 CKS1B (0.39) KDM4EALDH1A1CKS1BSKP1SKP2
SCHEMBL23055431 0.85 GRIN2B (0.38) GRIN2B
SCHEMBL23055344 0.76 KDM4E (0.43) KDM4EALDH1A1GRIN2B
SCHEMBL23639161 0.74 CKS1B (0.35) KDM4EALDH1A1CKS1BSKP1SKP2
SCHEMBL30328257 0.74 CYP11B2 (0.42) CKS1BSKP1SKP2RET
SCHEMBL29974035 0.73 PTPN11 (0.34) ALDH1A1CKS1BSKP1SKP2
Hydrochloric Acid SCHEMBL23045212 0.73 PTPN11 (0.34) ALDH1A1CKS1BSKP1SKP2
SCHEMBL23055615 0.72 GRIN2B (0.40) KDM4EALDH1A1GRIN2B
SCHEMBL30328474 0.71 CYP11B2 (0.41) CKS1BSKP1SKP2GRIN2BRET
SCHEMBL23055613 0.70 GRIN2B (0.41) GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230109839-A1 THERAPEUTIC AGENT FOR TAUOPATHIES Sumitomo Pharma Co., Ltd. (JP) 2023-04-13 US disclosed
EP-4104861-A1 THERAPEUTIC AGENT FOR TAUOPATHIES Sumitomo Pharma Co., Ltd. (JP) 2022-12-21 EP disclosed
WO-2021141041-A1 THERAPEUTIC AGENT FOR TAUOPATHIES 大日本住友製薬株式会社 2021-07-15 WO disclosed
WO-2021039961-A1 RING-FUSED PYRAZOLE DERIVATIVE 大日本住友製薬株式会社 2021-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230109839-A1 THERAPEUTIC AGENT FOR TAUOPATHIES MAPT, PSEN1, PSEN2 KDM4E 3621/4885ALDH1A1 4081/4885CKS1B 2532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.