Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | NAPEPLD | Q6IQ20 | 6/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310121 | 0.84 | MAPT (0.41) | MAPTVCPMTNR1AOPRM1OPRK1 | |
| SCHEMBL2305587 | 0.80 | MAPT (0.39) | MAPTVCPMTNR1AOPRM1OPRK1 | |
| SCHEMBL2306720 | 0.79 | MAPT (0.38) | MAPTOPRM1 | |
| SCHEMBL2304618 | 0.79 | MAPT (0.38) | MAPTVCPMTNR1AOPRM1OPRD1 | |
| SCHEMBL2305350 | 0.77 | OPRM1 (0.37) | MAPTOPRM1 | |
| SCHEMBL2307521 | 0.76 | ACHE (0.38) | — | |
| SCHEMBL493155 | 0.76 | SMN1; SMN2 (0.50) | MAPTNAPEPLD | |
| SCHEMBL493639 | 0.73 | MAPT (0.44) | MAPTNAPEPLD | |
| SCHEMBL2308192 | 0.71 | NPC1 (0.35) | MAPTMTNR1AOPRM1OPRK1 | |
| SCHEMBL1327183 | 0.69 | CHRNB2 (0.39) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989174-B1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-08-03 | — | — | EP | claimed |
| JP-2009520720-A | — | — | 2009-05-28 | — | — | JP | claimed |
| EP-1989174-A1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-12 | — | — | EP | claimed |
| WO-2007079930-A1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | claimed |
| EP-1989174-B1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| EP-1989174-A1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007079930-A1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |