Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 7/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30188516 | 0.90 | KMO (0.43) | KMOKDM4EALDH1A1EGFRPLA2G4A | |
| SCHEMBL23631639 | 0.85 | KMO (0.59) | KMOIRAK4FGFR1FGFR4BRD4 | |
| SCHEMBL24782853 | 0.85 | KMO (0.45) | KMOBRD4KDM4EALDH1A1PLA2G4A | |
| SCHEMBL7256650 | 0.83 | KMO (0.56) | KMOIRAK4FGFR1FGFR4BRD4 | |
| SCHEMBL5281382 | 0.81 | KDM4E (0.52) | KMOKDM4EALDH1A1 | |
| SCHEMBL31103887 | 0.80 | ALDH1A1 (0.36) | KMOFGFR1FGFR4BRD4KDM4E | |
| SCHEMBL23631662 | 0.79 | KMO (0.74) | KMOIRAK4FGFR1FGFR4EGFR | |
| SCHEMBL23631582 | 0.79 | KMO (0.52) | KMOIRAK4FGFR1FGFR4BRD4 | |
| SCHEMBL28803196 | 0.78 | SYK (0.44) | KMOKDM4EALDH1A1PLA2G4AHTR1A | |
| SCHEMBL9796 | 0.77 | KMO (0.46) | KMOIRAK4FGFR1FGFR4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021141041-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | 大日本住友製薬株式会社 | 2021-07-15 | — | — | WO | disclosed |
| WO-2021039961-A1 | RING-FUSED PYRAZOLE DERIVATIVE | 大日本住友製薬株式会社 | 2021-03-04 | — | — | WO | disclosed |