Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23055588 | 0.85 | KMO (0.55) | KMOKDM4EALDH1A1BRD4PLA2G4A | |
| SCHEMBL5281382 | 0.81 | KDM4E (0.52) | KMOKDM4EALDH1A1POLBTSHR | |
| SCHEMBL8013427 | 0.81 | KMO (0.51) | KMOALDH1A1BRD4HTR2AHTR2C | |
| SCHEMBL28803196 | 0.78 | SYK (0.44) | KMOKDM4EALDH1A1PLA2G4AHTR2A | |
| SCHEMBL8007487 | 0.78 | KMO (0.43) | KMOKDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL7997838 | 0.78 | KMO (0.43) | KMOKDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL25702553 | 0.77 | GABRG2 (0.46) | KMOGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL30188516 | 0.77 | KMO (0.43) | KMOKDM4EALDH1A1PLA2G4A | |
| SCHEMBL31219610 | 0.75 | HTR2A (0.40) | KMOHTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL31103887 | 0.75 | ALDH1A1 (0.36) | KMOKDM4EALDH1A1BRD4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4104861-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-21 | — | — | EP | disclosed |