Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 3/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29973522 | 1.00 | LIPE (0.33) | LIPECXCR2F2F11PRSS1 | |
| SCHEMBL18605166 | 0.88 | LIPE (0.33) | LIPECXCR2F2F11PRSS1 | |
| SCHEMBL14746407 | 0.82 | LIPE (0.37) | LIPECXCR2LPLLIPG | |
| SCHEMBL1356708 | 0.81 | MAPT (0.43) | CA1CA2CA9 | |
| SCHEMBL29973992 | 0.81 | MAPT (0.43) | CA1CA2CA9 | |
| SCHEMBL25368001 | 0.81 | SNCA (0.38) | LIPECXCR2CA1CA2CA9 | |
| SCHEMBL15912491 | 0.80 | LPL (0.38) | LIPECXCR2F2F11PRSS1 | |
| SCHEMBL31713106 | 0.79 | HRH4 (0.39) | LIPECXCR2 | |
| SCHEMBL26617400 | 0.77 | EGFR (0.31) | — | |
| SCHEMBL29973507 | 0.77 | GAA (0.46) | F2F11PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041970-A1 | PERK INHIBITING IMIDAZOLOPYRAZINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |
| WO-2021041973-A1 | PERK INHIBITING COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |