Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | EIF2AK3 | Q9NZJ5 | 6/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060898 | 1.00 | HAVCR2 (0.37) | HAVCR2CYP3A4EIF2AK3HSD11B2PLA2G7 | |
| SCHEMBL23043996 | 0.86 | CRHR1 (0.39) | HAVCR2EIF2AK3SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL29684355 | 0.86 | CRHR1 (0.39) | HAVCR2EIF2AK3SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL30060936 | 0.84 | DYRK1A (0.39) | CYP3A4EIF2AK3DYRK1AMETAXL | |
| SCHEMBL23057767 | 0.84 | DYRK1A (0.39) | CYP3A4EIF2AK3DYRK1AMETAXL | |
| SCHEMBL23057814 | 0.82 | DYRK1A (0.41) | EIF2AK3HTTDYRK1AKDM4EMAPT | |
| SCHEMBL20351612 | 0.79 | MET (0.41) | HAVCR2EIF2AK3SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL30060920 | 0.76 | DYRK1A (0.40) | CYP3A4EIF2AK3ADORA2AADORA1DYRK1A | |
| SCHEMBL23057898 | 0.72 | EIF2AK3 (0.51) | EIF2AK3METAXL | |
| SCHEMBL23057901 | 0.72 | KIT (0.40) | EIF2AK3MAPTALDH1A1METAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |