Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | EIF2AK3 | Q9NZJ5 | 11/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | SIK1 | P57059 | 1/20 | 0.37 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 4/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060936 | 1.00 | DYRK1A (0.39) | DYRK1AEIF2AK3RIPK2PDGFRBKIT | |
| SCHEMBL23043996 | 0.86 | CRHR1 (0.39) | DYRK1AEIF2AK3SRCAXLMET | |
| SCHEMBL29684355 | 0.86 | CRHR1 (0.39) | DYRK1AEIF2AK3SRCAXLMET | |
| SCHEMBL30060898 | 0.84 | HAVCR2 (0.37) | DYRK1AEIF2AK3AXLMETCYP3A4 | |
| SCHEMBL23057764 | 0.84 | HAVCR2 (0.37) | DYRK1AEIF2AK3AXLMETCYP3A4 | |
| SCHEMBL23057814 | 0.82 | DYRK1A (0.41) | DYRK1AEIF2AK3SRC | |
| SCHEMBL30060920 | 0.81 | DYRK1A (0.40) | DYRK1AEIF2AK3RIPK1AXLMET | |
| SCHEMBL20351494 | 0.80 | EIF2AK3 (0.52) | EIF2AK3RIPK2PDGFRBKITSRC | |
| SCHEMBL20351612 | 0.79 | MET (0.41) | DYRK1AEIF2AK3RIPK2SRCFLT3 | |
| SCHEMBL23057761 | 0.78 | EIF2AK3 (0.45) | DYRK1AEIF2AK3RIPK2RIPK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |