SCHEMBL23059720

SCHEMBL23059720

CN(CCC#N)c1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CTSS P25774 2/20 0.34
PTGES O14684 12/20 0.34
RXFP1 Q9HBX9 4/20 0.31
P2RX1 P51575 1/20 0.31
P2RX7 Q99572 1/20 0.31
MCHR1 Q99705 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23059604 0.95 CTSS (0.35) CTSSPTGESRXFP1
SCHEMBL23059707 0.94 CTSS (0.35) CTSSPTGESRXFP1
SCHEMBL23059691 0.91 CTSS (0.35) CTSSPTGESRXFP1P2RX1P2RX7
SCHEMBL24914489 0.86 CTSS (0.37) CTSSPTGESRXFP1
SCHEMBL24914808 0.84 CTSS (0.37) CTSSPTGESRXFP1P2RX1P2RX7
SCHEMBL25085560 0.82 GPBAR1 (0.35) PTGES
SCHEMBL22520725 0.82 RXFP1 (0.36) CTSSPTGESRXFP1
SCHEMBL23059717 0.81 PTGES (0.38) CTSSPTGESRXFP1
SCHEMBL1766651 0.81 RXFP1 (0.40) PTGESRXFP1MCHR1
SCHEMBL1766385 0.80 RXFP1 (0.41) RXFP1MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021036965-A1 ISOPHTHALAMIDE COMPOUND AND USE THEREOF 沈阳化工大学 2021-03-04 WO disclosed