Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 6/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855823 | 0.88 | GABRG2 (0.72) | CYP2A6GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2653411 | 0.83 | GABRG2 (0.66) | CYP2A6GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2074501 | 0.79 | CYP2A6 (0.54) | CYP2A6GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL30338888 | 0.77 | CYP2A6 (1.00) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL3614263 | 0.77 | CYP2A6 (1.00) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL20267348 | 0.75 | CYP2A6 (0.54) | CYP2A6GABRG2GABRB3GABRA5GABRA3 | |
| Pyrimidine SCHEMBL28261125 | 0.74 | CYP2A6 (0.85) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL10835353 | 0.74 | CYP2A6 (0.62) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL28013979 | 0.74 | CYP2A6 (0.83) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL30297729 | 0.74 | CYP2A6 (0.50) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-08-30 | — | — | US | disclosed |
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | UNIVERSITÄT BREMEN (DE) | 2021-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | TESK2, TESK1, PRKACB | CYP2A6 4768/4885GABRG2 3445/4885GABRB3 2852/4885 |
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | TESK2, TESK1, PRKACB | CYP2A6 4768/4885GABRG2 3445/4885GABRB3 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.