Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 5/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11752591 | 0.74 | ALDH1A1 (0.47) | RAD52AKR1B1CA12CA1CA2 | |
| SCHEMBL8111364 | 0.73 | RAD52 (0.39) | TGM2RAD52AKR1B1PGRCA12 | |
| SCHEMBL15621888 | 0.73 | RAD52 (0.43) | RAD52CA9MEN1KMT2AGAA | |
| SCHEMBL11386072 | 0.73 | CHEK1 (0.55) | TGM2CES1HTR2BRAD52CMA1 | |
| SCHEMBL31344378 | 0.72 | TGM2 (0.46) | TGM2CES1CMA1AHRBRD4 | |
| SCHEMBL31223925 | 0.72 | TGM2 (0.46) | TGM2CES1CMA1AHRBRD4 | |
| SCHEMBL3642313 | 0.69 | RAD52 (0.61) | RAD52SNCAMEN1KMT2AGAA | |
| SCHEMBL31394401 | 0.68 | BRD4 (0.46) | TGM2CES1CMA1AHRBRD4 | |
| SCHEMBL5031665 | 0.68 | ALDH1A1 (0.38) | RAD52 | |
| SCHEMBL14920957 | 0.68 | CMA1 (0.42) | TGM2CES1HTR2BSIGMAR1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187403-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| WO-2021041237-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-04 | — | — | WO | disclosed |