Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.82 |
| ▸ | IGF2BP1 | Q9NZI8 | 2/20 | 0.82 |
| ▸ | NPC1 | O15118 | 2/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | STAT3 | P40763 | 1/20 | 0.82 |
| ▸ | HTT | P42858 | 1/20 | 0.82 |
| ▸ | ATM | Q13315 | 1/20 | 0.82 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cucurbitacin D SCHEMBL8166627 | 1.00 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Cucurbitacin D SCHEMBL20121444 | 1.00 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| SCHEMBL10307568 | 0.95 | ITGAL (0.90) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| SCHEMBL21650384 | 0.92 | ITGAL (0.86) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Amarin SCHEMBL17531553 | 0.90 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Amarin SCHEMBL19186443 | 0.90 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Cucurbitacin B SCHEMBL29602393 | 0.90 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Amarin SCHEMBL22433345 | 0.90 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Amarin SCHEMBL18177462 | 0.90 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 | |
| Amarin SCHEMBL13668120 | 0.90 | ITGAL (1.00) | ITGALSMN1; SMN2HIF1AIGF2BP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 292 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024162488-A1 | PHARMACEUTICAL COMPOSITION COMPRISING CUCURBITACIN D FOR PREVENTING OR TREATING NEUROPATHIC PAIN | 주식회사 재인알앤피 | 2024-08-08 | — | — | WO | claimed |
| CN-116381117-A | Method for constructing graph of snakegourd, allium macrostemon and pinellia ternate Shang Zhiwen and measuring content of index components | 澳门科技大学 | 2023-07-04 | — | — | CN | claimed |
| CN-116124958-A | Method for constructing fingerprint spectrum of medicinal material of snakegourd fruit and measuring content of index components of snakegourd fruit | 澳门科技大学 | 2023-05-16 | — | — | CN | claimed |
| CN-114681371-A | Trichosanthes and bitter apricot seed compound extract, preparation method thereof and mask prepared from same | 上海小方制药股份有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-114681375-A | Refined extract of snakegourd fruit and bitter almond and preparation method thereof | 上海小方制药股份有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-110590892-B | Triterpene compound with anti-tumor activity separated from waste fructus Trichosanthis pulp and its application | 南京中医药大学 | 2021-06-22 | — | — | CN | claimed |
| EP-2083828-B1 | A STANDARDISED EXTRACT AND ITS USE IN THE MANUFACTURE OF A MEDICAMENT | BOTANIC CENTURY BEIJING CO LTD (CN) | 2020-01-29 | — | — | EP | claimed |
| CN-110041392-A | A kind of preparation method of cucurbitacin D | 浙江工业大学 | 2019-07-23 | — | — | CN | claimed |
| CN-108659087-A | A kind of extraction process of cucurbitacin D | 湖州展舒生物科技有限公司 | 2018-10-16 | — | — | CN | claimed |
| US-10076527-B2 | Standardized extract and its use in the manufacture of a medicament | BOTANIC CENTURY (BEIJING) CO., LTD. (CN) | 2018-09-18 | — | — | US | claimed |
| WO-2007138239-A1 | CUCURBITACINE ANALOGS OR AN EXTRACT FROM TRICHOSANTHES FOR TREATING ANEMIA | ULTRA BIOTECH LIMITED (GB) | 2007-12-06 | — | — | WO | claimed |
| WO-2007130523-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTION | GEORGE MASON INTELLECTUAL PROPERTIES, INC. (US) | 2007-11-15 | — | — | WO | claimed |
| CN-1919339-A | Cucurbitacin nano preparation comprising protein, preparation method and use thereof | MEDICINE SUBJECT UNIVERSITY OF (CN) | 2007-02-28 | — | — | CN | claimed |
| CN-1883484-A | Novel pharmacological use of cucurbitacine | UNIV SHENYANG PHARMACEUTICAL (CN) | 2006-12-27 | — | — | CN | claimed |
| US-20060246161-A1 | METHOD OF MAKING MEDICAMENT FOR TREATING ANEMIA | ULTRA BIOTECH LIMITED (GB) | 2006-11-02 | — | — | US | claimed |
| WO-2005022167-A2 | COMPOUNDS THAT ACT TO MODULATE INSECT GROWTH AND METHODS AND SYSTEMS FOR IDENTIFYING SUCH COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2005-03-10 | — | — | WO | claimed |
| US-20050049230-A1 | Compounds that act to modulate insect growth and methods and systems for identifying such compounds | UNIVERSITY OF NORTH CAROLINA AT GREENSBORO, THE | 2005-03-03 | — | — | US | claimed |
| US-20040138189-A1 | Moderation of intracellular signals; antitumor agents; drug screening; administering cucurbitacin compound | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-07-15 | — | — | US | claimed |
| WO-2002078617-A2 | MATERIALS AND METHODS FOR TREATMENT OF CANCER AND IDENTIFICATION OF ANTI-CANCER COMPOUNDS | UNIVERSITY OF SOUTH FLORIDA (US) | 2002-10-10 | — | — | WO | claimed |
| US-5925356-A | Method of isolating cucurbitacin | JP MORGAN CHASE BANK | 1999-07-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049230-A1 | Compounds that act to modulate insect growth and methods and systems for identifying such compounds | FXR2, FXR1, NR1H2 | ITGAL 3967/4885SMN1; SMN2 4482/4885HIF1A 4698/4885 |
| US-20060246161-A1 | METHOD OF MAKING MEDICAMENT FOR TREATING ANEMIA | HBG1, HBG2, HBZ | ITGAL 1266/4885SMN1; SMN2 2007/4885HIF1A 69/4885 |
| US-20040138189-A1 | Moderation of intracellular signals; antitumor agents; drug screening; administering cucurbitacin compound | STAT3, STAT1, JAK2 | ITGAL 4681/4885SMN1; SMN2 4227/4885HIF1A 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.