Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.54 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23065565 | 1.00 | LTA4H (0.61) | LTA4HHTTPSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL29520137 | 0.99 | LTA4H (0.60) | LTA4HHTTPSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL23045049 | 0.99 | LTA4H (0.60) | LTA4HHTTPSMB1PSMB5PSMB2 | |
| SCHEMBL23065571 | 0.94 | NPC1 (0.58) | LTA4HHTTHRH3NPC1RAB9A | |
| SCHEMBL23065574 | 0.94 | NPC1 (0.58) | LTA4HHTTHRH3NPC1RAB9A | |
| SCHEMBL23065576 | 0.89 | LTA4H (0.58) | LTA4HHTTPSMB1PSMB5NPC1 | |
| SCHEMBL4246615 | 0.86 | NOS3 (0.62) | LTA4HHRH3SMN1; SMN2NOS3NOS1 | |
| SCHEMBL26185877 | 0.86 | LTA4H (0.61) | LTA4HHTTPSMB1PSMB5PSMB2 | |
| SCHEMBL23065577 | 0.84 | LTA4H (0.60) | LTA4HHRH3NOS3NOS1NOS2 | |
| SCHEMBL29374406 | 0.84 | LTA4H (0.58) | LTA4HHTTPSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271928-A1 | NAPHTHYLUREA COMPOUND, METHODS OF PREPARATION AND USE THEREOF | HENAN RADIOMEDICAL SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| US-20230271928-A1 | NAPHTHYLUREA COMPOUND, METHODS OF PREPARATION AND USE THEREOF | HENAN RADIOMEDICAL SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| US-20230271928-A1 | NAPHTHYLUREA COMPOUND, METHODS OF PREPARATION AND USE THEREOF | HENAN RADIOMEDICAL SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| WO-2022166994-A1 | NAPHTHYL UREA COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 河南省锐达医药科技有限公司 | 2022-08-11 | — | — | WO | disclosed |
| US-20220098162-A1 | APHTHYLAMINE COMPOUND AND BIOLOGICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | HENAN RADIOMEDICAL SCIENCE AND TECH CO LTD (CN) | 2022-03-31 | — | — | US | disclosed |
| CN-112961120-B | Naphthyl urea compound, preparation method and application thereof | 河南省锐达医药科技有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-112961120-A | Naphthyl urea compound, preparation method and application thereof | 河南省锐达医药科技有限公司 | 2021-06-15 | — | — | CN | disclosed |
| WO-2021037090-A1 | NAPHTHYLAMINE COMPOUND AND BIOLOGICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 河南省锐达医药科技有限公司 | 2021-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098162-A1 | APHTHYLAMINE COMPOUND AND BIOLOGICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | HASPIN, SLC7A1, INMT | LTA4H 2061/4885HTT 1167/4885PSMB1 4801/4885 |
| US-20230271928-A1 | NAPHTHYLUREA COMPOUND, METHODS OF PREPARATION AND USE THEREOF | C1R, C9, H1-3 | LTA4H 3127/4885HTT 2024/4885PSMB1 2606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.