Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12430197 | 0.98 | HDAC11 (0.51) | HDAC11CHEK2POLBCSNK1A1CSNK1D | |
| SCHEMBL12266215 | 0.90 | HDAC11 (0.46) | HDAC11CHEK2POLBCSNK1A1CSNK1D | |
| SCHEMBL1748082 | 0.86 | DGAT1 (0.50) | HDAC11POLBDGAT1 | |
| SCHEMBL1748083 | 0.86 | DGAT1 (0.50) | HDAC11POLBDGAT1 | |
| SCHEMBL1748084 | 0.86 | DGAT1 (0.50) | HDAC11POLBDGAT1 | |
| Bicarbonate SCHEMBL2307781 | 0.84 | P2RY14 (0.42) | CHEK2POLBCSNK1A1CSNK1DCSNK1G2 | |
| Bicarbonate SCHEMBL2316045 | 0.84 | SMN1; SMN2 (0.56) | CHEK2POLBCSNK1A1CSNK1DCSNK1G2 | |
| Bicarbonate SCHEMBL2313113 | 0.82 | RAB9A (0.47) | CHEK2POLBKDM4EMEN1LMNA | |
| Bicarbonate SCHEMBL2310230 | 0.79 | NPC1 (0.52) | CHEK2POLBKDM4EMEN1MAPT | |
| Bicarbonate SCHEMBL2312392 | 0.77 | DGAT1 (0.41) | CHEK2POLBCSNK1DCSNK1G2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |