Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 6/20 | 0.43 |
| ▸ | MERTK | Q12866 | 6/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777485 | 0.97 | POLB (0.45) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL25360179 | 0.92 | MET (0.48) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL21777782 | 0.89 | AXL (0.43) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL28576707 | 0.89 | POLB (0.42) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL19377776 | 0.85 | ALDH1A1 (0.49) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL21777641 | 0.84 | POLB (0.41) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL23070982 | 0.84 | AXL (0.44) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL21778083 | 0.83 | GPR119 (0.41) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL14968986 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL29937597 | 0.82 | AXL (0.44) | KDM4EALDH1A1TP53HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283916-B | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2024-06-11 | — | — | CN | disclosed |
| CN-116283916-A | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-112457295-B | Compound with Axl and c-Met kinase inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2022-07-26 | — | — | CN | disclosed |
| EP-4029862-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-07-20 | — | — | EP | disclosed |
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |
| CN-112457295-A | Compound with Axl and c-Met kinase inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-03-09 | — | — | CN | disclosed |