Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | YTHDF3 | Q7Z739 | 2/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.44 |
| ▸ | YTHDF1 | Q9BYJ9 | 2/20 | 0.44 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3300276 | 0.71 | PNMT (0.65) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL21384198 | 0.70 | TP53 (0.55) | PNMTMPOTAAR1CYP3A4IDO1 | |
| SCHEMBL29442835 | 0.70 | TP53 (0.55) | PNMTMPOTAAR1CYP3A4IDO1 | |
| SCHEMBL18148766 | 0.70 | MPO (0.47) | PNMTYTHDF3YTHDC1YTHDF1YTHDF2 | |
| SCHEMBL22968941 | 0.69 | PDE4B (0.52) | PNMTHCAR2TAAR1CYP3A4IDO1 | |
| SCHEMBL1300757 | 0.69 | HTR2C (0.50) | PNMTMPOTAAR1CYP3A4IDO1 | |
| SCHEMBL7397450 | 0.69 | MPO (0.49) | PNMTYTHDF3YTHDC1YTHDF1YTHDF2 | |
| SCHEMBL16401423 | 0.69 | YTHDF3 (0.44) | PNMTYTHDF3YTHDC1YTHDF1YTHDF2 | |
| SCHEMBL18586524 | 0.68 | MPO (0.55) | PNMTMPOTAAR1CYP3A4IDO1 | |
| SCHEMBL11778511 | 0.68 | PNMT (0.52) | PNMTMPOTAAR1CYP3A4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348860-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | Genentech, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010051549-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-05-06 | — | — | WO | disclosed |