SCHEMBL23081593

SCHEMBL23081593

CC(C)(C)OC(=O)NNCc1cnccn1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
RAB9A P51151 2/20 0.41
VNN1 O95497 4/20 0.39
NAMPT P43490 3/20 0.39
KDM4E B2RXH2 1/20 0.38
CYP3A4 P08684 1/20 0.38
HPGDS O60760 1/20 0.37
APLNR P35414 1/20 0.36
GAA P10253 2/20 0.36
CYP17A1 P05093 1/20 0.36
GPR119 Q8TDV5 1/20 0.36
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP2C9 P11712 1/20 0.35
LATS1 O95835 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30525777 1.00 HDAC3 (0.42) HDAC3HDAC1HDAC2HDAC6RAB9A
SCHEMBL1265671 0.85 NAMPT (0.48) HDAC3HDAC1HDAC2HDAC6RAB9A
SCHEMBL30089199 0.85 NAMPT (0.48) HDAC3HDAC1HDAC2HDAC6RAB9A
SCHEMBL5749 0.78 CYP17A1 (0.44) RAB9ANAMPTCYP3A4GAACYP17A1
SCHEMBL23070376 0.77 VNN1 (0.49) HDAC3HDAC1HDAC2HDAC6VNN1
SCHEMBL9439389 0.76 CYP3A4 (0.59) RAB9ANAMPTKDM4ECYP3A4GAA
SCHEMBL21847323 0.75 NAMPT (0.40) RAB9ANAMPTCYP3A4APLNRGAA
SCHEMBL27838788 0.75 RAB9A (0.44) RAB9ANAMPTKDM4EGAAGPR119
SCHEMBL17963188 0.75 CYP17A1 (0.53) RAB9ANAMPTCYP3A4GAACYP17A1
SCHEMBL21692809 0.74 KDM4E (0.36) RAB9AKDM4EAPLNRGAACYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021046515-A1 INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-03-11 WO disclosed