Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 10/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21510296 | 0.86 | NTRK1 (0.49) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29088903 | 0.86 | NTRK1 (0.49) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23083890 | 0.86 | NTRK1 (0.55) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18361444 | 0.83 | NTRK1 (0.49) | NTRK1NTRK3NTRK2AAK1 | |
| SCHEMBL23083841 | 0.83 | NTRK1 (0.45) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21510573 | 0.81 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL22996460 | 0.80 | AAK1 (0.36) | NTRK1NTRK3NTRK2AAK1 | |
| SCHEMBL21510292 | 0.80 | NTRK1 (0.53) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18361547 | 0.79 | NTRK1 (0.51) | NTRK1NTRK3NTRK2 | |
| SCHEMBL28491933 | 0.79 | NTRK1 (0.54) | NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |