Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2314871 | 0.91 | DGAT1 (0.51) | DGAT1KMT2AMEN1CTSSCTSL | |
| Bicarbonate SCHEMBL2311135 | 0.89 | DGAT1 (0.44) | DGAT1KMT2AGAARAB9AMAPT | |
| SCHEMBL2307357 | 0.88 | DGAT1 (0.58) | DGAT1KCNH2KMT2AMEN1GAA | |
| SCHEMBL2311010 | 0.88 | DGAT1 (0.58) | DGAT1KCNH2KMT2AMEN1GAA | |
| SCHEMBL2307361 | 0.88 | DGAT1 (0.58) | DGAT1KCNH2KMT2AMEN1GAA | |
| Bicarbonate SCHEMBL2314686 | 0.87 | DGAT1 (0.46) | DGAT1KMT2AMEN1RAB9AMAPT | |
| Bicarbonate SCHEMBL2309024 | 0.87 | RAB9A (0.43) | DGAT1KCNH2KMT2AMEN1GAA | |
| Bicarbonate SCHEMBL2308797 | 0.85 | DGAT1 (0.49) | DGAT1KCNH2KMT2AMEN1GAA | |
| Bicarbonate SCHEMBL2359226 | 0.84 | DGAT1 (0.42) | DGAT1KCNH2KMT2ARAB9AMAPT | |
| Bicarbonate SCHEMBL2308864 | 0.82 | DGAT1 (0.41) | DGAT1KCNH2KMT2AMEN1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |