Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS2 | Q07890 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742391 | 0.89 | GRM5 (0.43) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL995983 | 0.83 | SOS2 (0.50) | SOS2CTSKCTSSKDM4EALDH1A1 | |
| SCHEMBL24618603 | 0.81 | SOS2 (0.39) | SOS2CTSKCTSSKDM4EMEN1 | |
| SCHEMBL22846483 | 0.78 | GRM5 (0.37) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL26178688 | 0.78 | GRM5 (0.37) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL26381449 | 0.78 | CTSK (0.39) | SOS2CTSKCTSSKDM4EMEN1 | |
| SCHEMBL23075939 | 0.76 | GRM5 (0.62) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL9949090 | 0.74 | GRM5 (0.37) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL9137033 | 0.74 | GRM5 (0.37) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL17039219 | 0.74 | NOS3 (0.46) | KDM4EMEN1NPC1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |