Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 7/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23085749 | 0.81 | MAP3K14 (0.37) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL23081626 | 0.81 | MAP3K14 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL25586411 | 0.80 | GRM5 (0.40) | RIPK1PDE3BPDE3AMAP3K14GRM5 | |
| SCHEMBL23085715 | 0.79 | RIPK1 (0.45) | RIPK1PDE3BPDE3AMAP3K14GRM5 | |
| SCHEMBL22590505 | 0.79 | MAP3K14 (0.57) | RIPK1MAP3K14 | |
| SCHEMBL15964515 | 0.78 | PDE3B (0.43) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL12713588 | 0.78 | KMO (0.46) | PDE3BPDE3A | |
| SCHEMBL15964655 | 0.78 | TRPV1 (0.44) | PDE3BPDE3AKRASSOS1TRPV1 | |
| SCHEMBL23085596 | 0.77 | RIPK1 (0.46) | RIPK1MAP3K14GRM5 | |
| SCHEMBL23085717 | 0.77 | RIPK1 (0.46) | RIPK1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248975-A2 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |