Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 10/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PEPD | P12955 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL2306596 | 0.85 | POLB (0.41) | DPP4PREPFAPACEHSD17B10 | |
| SCHEMBL3259037 | 0.81 | DPP4 (0.43) | DPP4PREPFAPDPP8DPP9 | |
| Glycine SCHEMBL7698164 | 0.78 | ACE (0.42) | ACERENLMNAHSD17B10CYP2C19 | |
| Glycine SCHEMBL1537349 | 0.78 | ACE (0.42) | ACERENLMNAHSD17B10CYP2C19 | |
| Glycine SCHEMBL22589756 | 0.76 | ACE (0.41) | ACERENLMNAHSD17B10CYP2C19 | |
| Glycine SCHEMBL28184501 | 0.76 | ACE (0.45) | ACERENLMNAHSD17B10CYP2C19 | |
| Glycyl Proline SCHEMBL28116177 | 0.75 | ACE (0.58) | DPP4PREPFAPDPP8DPP9 | |
| Glycyl Proline SCHEMBL28116179 | 0.75 | ACE (0.58) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL11990391 | 0.73 | ACE (0.41) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL85497 | 0.73 | ACE (0.41) | ACERENLMNAHSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150320892-A1 | IMAGING FIBROSIS | GE HEALTHCARE LIMITED (GB) | 2015-11-12 | — | — | US | disclosed |
| EP-2866842-A1 | IMAGING FIBROSIS | GE Healthcare UK Limited (GB) | 2015-05-06 | — | — | EP | disclosed |
| WO-2014001538-A1 | IMAGING FIBROSIS | GE HEALTHCARE LIMITED (GB) | 2014-01-03 | — | — | WO | disclosed |
| EP-2349995-A1 | SELECTIVE SEPRASE INHIBITORS | Molecular Insight Pharmaceuticals, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20100098633-A1 | SELECTIVE SEPRASE INHIBITORS | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2010-04-22 | — | — | US | disclosed |
| WO-2010036814-A1 | SELECTIVE SEPRASE INHIBITORS | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150320892-A1 | IMAGING FIBROSIS | SLC10A1, RHOA, MMP1 | DPP4 1177/4885PREP 1245/4885FAP 269/4885 |
| US-20100098633-A1 | SELECTIVE SEPRASE INHIBITORS | SLC6A7, DNPEP, PREP | DPP4 472/4885PREP 3/4885FAP 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.