Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | UQCRB | P14927 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.51 |
| ▸ | FABP1 | P07148 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20117565 | 0.82 | PTPRC (0.47) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10093389 | 0.82 | POLB (0.54) | POLBUQCRBHDAC3HDAC4HDAC1 | |
| SCHEMBL10093392 | 0.81 | POLB (0.51) | POLBUQCRBHDAC3HDAC4HDAC1 | |
| SCHEMBL2309959 | 0.81 | POLB (0.51) | POLBUQCRBHDAC3HDAC4HDAC1 | |
| SCHEMBL2236940 | 0.81 | CYP19A1 (0.54) | POLBNAMPTGAAMEN1KMT2A | |
| SCHEMBL10093362 | 0.81 | L3MBTL1 (0.46) | POLBNAMPTERAP1ALDH1A1 | |
| SCHEMBL812691 | 0.81 | POLB (0.67) | POLBUQCRBHDAC3HDAC4HDAC1 | |
| SCHEMBL10169497 | 0.80 | HTR6 (0.59) | POLBERAP1GAAHPGDMEN1 | |
| SCHEMBL14125611 | 0.79 | CA12 (0.63) | POLBUQCRBHDAC3HDAC4HDAC1 | |
| SCHEMBL6297524 | 0.79 | HSD17B2 (0.70) | POLBUQCRBHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-A1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | Pimco 2664 Limited (GB) | 2011-08-03 | — | — | EP | disclosed |