SCHEMBL230930

SCHEMBL230930

O=C(c1ccccc1)c1cc(Cl)ccc1Cl

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.63
MAPT P10636 3/20 0.63
LMNA P02545 2/20 0.63
TP53 P04637 4/20 0.62
CNR2 P34972 1/20 0.59
HTT P42858 2/20 0.58
NPSR1 Q6W5P4 2/20 0.58
MITF O75030 1/20 0.58
HSP90AA1 P07900 1/20 0.58
ATM Q13315 1/20 0.58
TLR9 Q9NR96 1/20 0.58
NR4A1 P22736 1/20 0.55
SRD5A2 P31213 1/20 0.54
RECQL P46063 1/20 0.54
S100B P04271 1/20 0.54
SERPINE1 P05121 1/20 0.53
GABRP O00591 1/20 0.52
GABRD O14764 1/20 0.52
GABRA1 P14867 1/20 0.52
GABRB1 P18505 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29612638 1.00 ALDH1A1 (0.63) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL13309938 0.96 CNR2 (0.60) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL13309942 0.96 CNR2 (0.60) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL17134428 0.93 ALDH1A1 (0.57) ALDH1A1MAPTLMNATP53CNR2
Acetamide SCHEMBL28069463 0.92 ALDH1A1 (0.56) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL31474389 0.90 MEN1 (0.57) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL5545798 0.90 MEN1 (0.57) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL31474388 0.90 MEN1 (0.57) ALDH1A1MAPTLMNATP53CNR2
SCHEMBL7466437 0.88 ALDH1A1 (0.61) ALDH1A1MAPTLMNATP53NR4A1
SCHEMBL12360590 0.87 POLB (0.56) ALDH1A1MAPTLMNATP53CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 474 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102471494-B star polymer Robert Bosch Ltd. (DE) 2015-11-25 CN claimed
US-9127129-B2 Star polymer ROBERT BOSCH GMBH (DE) 2015-09-08 US claimed
US-20120238699-A1 STAR POLYMER ROBERT BOSCH GMBH (DE) 2012-09-20 US claimed
CN-102471494-A Star polymer BOSCH GMBH ROBERT 2012-05-23 CN claimed
EP-0629217-B1 RIGID-ROD POLYMERS MISSISSIPPI POLYMER TECHNOLOGI (US) 2003-05-07 EP claimed
JP-3245166-B2 2002-01-07 JP claimed
US-5646232-A MANUFACTURING POLYPHENYL RESINS MAXDEM INCORPORATED (US) 1997-07-08 US claimed
US-5602228-A Nickel phosphate catalysts MAXDEM INCORPORATED (US) 1997-02-11 US claimed
WO-1996039455-A1 NICKEL PHOSPHITE CATALYSTS MAXDEM INCORPORATED (US) 1996-12-12 WO claimed
EP-0629217-A4 RIGID-ROD POLYMERS. MAXDEM INC (US) 1995-03-29 EP claimed
EP-0629217-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1994-12-21 EP claimed
WO-1993018076-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1993-09-16 WO claimed
WO-1993014055-A1 PREPARATION OF 2,5-DICHLOROBENZOPHENONES MAXDEM INCORPORATED (US) 1993-07-22 WO claimed
US-5210313-A Friedel crafts aryloylation of 1,4-dichlorobenzene and Lewis acids MAXDEM INCORPORATED (US) 1993-05-11 US claimed
JP-62116549-A None JP disclosed
JP-62114944-A None JP disclosed
JP-9309945-A None JP disclosed
EP-0045519-A2 Pyrrolo-(3,4-d)-benzapines, process and intermediates for their preparation and pharmaceutical compositions containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-02-10 EP disclosed
EP-0045521-A1 Pyrazolobenzazepines, process for their preparation and pharmaceutical compositions containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-02-10 EP disclosed
EP-0039795-A1 Process for the preparation of 1,2-benzisothiazoles BASF Aktiengesellschaft (DE) 1981-11-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120238699-A1 STAR POLYMER STARD3, STARD10, STARD7 ALDH1A1 4777/4885MAPT 2803/4885LMNA 1204/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.