Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | ATM | Q13315 | 2/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23094236 | 0.86 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094243 | 0.83 | L3MBTL1 (0.80) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094244 | 0.81 | L3MBTL1 (0.69) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094253 | 0.80 | L3MBTL1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094168 | 0.80 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094199 | 0.79 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094277 | 0.79 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094164 | 0.79 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094247 | 0.78 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM | |
| SCHEMBL23094156 | 0.78 | TDP1 (1.00) | ALDH1A1KDM4ETDP1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | ALDH1A1 845/4885KDM4E 2315/4885TDP1 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.