Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27374179 | 0.93 | TDP1 (0.69) | TDP1L3MBTL1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL23094207 | 0.88 | TDP1 (0.78) | TDP1L3MBTL1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL9809465 | 0.86 | TDP1 (0.66) | TDP1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL27374100 | 0.82 | NPC1 (0.66) | TDP1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL23094277 | 0.82 | TDP1 (1.00) | TDP1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30750934 | 0.81 | MAPT (0.84) | TDP1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL27374467 | 0.81 | MAPT (0.84) | TDP1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL23094156 | 0.81 | TDP1 (1.00) | TDP1L3MBTL1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL23094218 | 0.80 | TDP1 (0.58) | TDP1L3MBTL1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL31503214 | 0.78 | NPC1 (0.61) | TDP1L3MBTL1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | TDP1 4664/4885L3MBTL1 2077/4885MAPT 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.