Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2312012 | 0.83 | HSP90AB1 (0.45) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL2315193 | 0.82 | CDK1 (0.46) | CDK2ATR | |
| SCHEMBL2311699 | 0.82 | HSP90AB1 (0.45) | AURKA | |
| SCHEMBL2314905 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1MAPTHPGD | |
| SCHEMBL22955477 | 0.80 | KDR (0.55) | KDRPDGFRBFGFR1BTKALDH1A1 | |
| SCHEMBL2311056 | 0.79 | ATR (0.48) | ALDH1A1MAPTMEN1KMT2AATR | |
| SCHEMBL2314500 | 0.79 | HSP90AB1 (0.43) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL2314109 | 0.78 | HSP90AB1 (0.43) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL2311956 | 0.78 | RAB9A (0.54) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL20765466 | 0.77 | ALDH1A1 (0.64) | KDRPDGFRBFGFR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888579-B1 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA SA (FR) | 2011-08-03 | — | — | EP | disclosed |
| EP-1888579-A2 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | Aventis Pharma S.A. (FR) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006123061-A2 | FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2006-11-23 | — | — | WO | disclosed |