⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2691144 | 0.79 | — | — | |
| SCHEMBL302005 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL8122291 | 0.78 | — | — | |
| SCHEMBL643818 | 0.72 | — | — | |
| SCHEMBL28326572 | 0.72 | — | — | |
| SCHEMBL3245144 | 0.69 | — | — | |
| SCHEMBL28266530 | 0.68 | CA1 (0.30) | — | |
| Cyclohexanone SCHEMBL28357381 | 0.67 | TRIM24 (0.34) | — | |
| SCHEMBL3602257 | 0.67 | — | — | |
| SCHEMBL7089078 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301110-A | Novel tetrahydroisoquinoline compounds, preparation method thereof, pharmaceutical composition containing compounds and application of compounds | 中国科学院上海药物研究所 | 2025-01-10 | — | — | CN | claimed |
| CN-117126134-A | Novel tetrahydroisoquinoline compounds, preparation method thereof, pharmaceutical composition containing compounds and application of compounds | 中国科学院上海药物研究所 | 2023-11-28 | — | — | CN | claimed |
| CN-115087653-B | Pharmaceutical application of aldehyde compound | 中国科学院上海药物研究所 | 2023-11-17 | — | — | CN | claimed |
| CN-111712491-B | Tetrahydroisoquinoline compounds, preparation method thereof, pharmaceutical composition containing compounds and application of compounds | 中国科学院上海药物研究所 | 2023-11-17 | — | — | CN | claimed |
| US-20230138310-A1 | PHARMACEUTICAL USE OF ALDEHYDE-BASED COMPOUND | FRONTIER BIOTECHNOLOGIES INC. (CN) | 2023-05-04 | — | — | US | claimed |
| EP-4098653-A1 | PHARMACEUTICAL USE OF ALDEHYDE-BASED COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-12-07 | — | — | EP | claimed |
| CN-115087653-A | Medicinal application of aldehyde compound | 中国科学院上海药物研究所 | 2022-09-20 | — | — | CN | claimed |
| CN-113181339-B | Medicinal application of aldehyde compound | 中国科学院上海药物研究所 | 2022-02-22 | — | — | CN | claimed |
| CN-113620929-A | Aldehyde group compound and preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2021-11-09 | — | — | CN | claimed |
| WO-2021151265-A1 | PHARMACEUTICAL USE OF ALDEHYDE-BASED COMPOUND | 中国科学院上海药物研究所 | 2021-08-05 | — | — | WO | claimed |
| US-8835418-B2 | Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2014-09-16 | — | — | US | claimed |
| US-20130165422-A1 | HEXAFLUOROISOPROPYL CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2013-06-27 | — | — | US | claimed |
| EP-2576507-A1 | HEXAFLUOROISOPROPYL CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2013-04-10 | — | — | EP | claimed |
| WO-2011151808-A1 | HEXAFLUOROISOPROPYL CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2011-12-08 | — | — | WO | claimed |
| US-7667053-B2 | Cannabinoid-1 (CB1) receptor antagonists and/or inverse agonists; e.g. N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-1,4-benzodioxane-2-carboxamide; psychological disorders, eating disorders | MERCK & CO., INC. (US) | 2010-02-23 | — | — | US | claimed |
| EP-1725547-A1 | PROCESS FOR PREPARING N-ARYL-PIPERAZINE DERIVATIVES CROSS-REFERENCE TO RELATED APPLICATIONS | Wyeth (US) | 2006-11-29 | — | — | EP | claimed |
| WO-2005092883-A1 | PROCESS FOR PREPARING N-ARYL-PIPERAZINE DERIVATIVES | WYETH (US) | 2005-10-06 | — | — | WO | claimed |
| US-20050209245-A1 | Process for preparing N-aryl-piperazine derivatives | WYETH (US) | 2005-09-22 | — | — | US | claimed |
| US-5135927-A | 2-chloro-4-trifluoromethylthiazol-5-carboxylic acid | CIBA-GEIGY CORPORATION (US) | 1992-08-04 | — | — | US | claimed |
| US-4992434-A | Prevention of infestation of plants by phytopathogenic microorganisms | CIBA-GEIGY CORPORATION (US) | 1991-02-12 | — | — | US | claimed |