Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23104094 | 0.86 | PDE10A (0.49) | GPR119PDE10APIK3CDCKS1BSKP1 | |
| SCHEMBL29736507 | 0.82 | PDE10A (0.54) | GPR119PDE10APIK3CDHSD11B1MAP4K4 | |
| SCHEMBL23104005 | 0.82 | PDE10A (0.54) | GPR119PDE10APIK3CDHSD11B1MAP4K4 | |
| SCHEMBL4339043 | 0.79 | CCR5 (0.45) | CCR5GPR119 | |
| SCHEMBL23104168 | 0.77 | PDE10A (0.48) | GPR119PDE10APIK3CDHSD11B1MAP4K4 | |
| SCHEMBL23104598 | 0.76 | KIF18A (0.53) | PDE10APIK3CDHSD11B1MAP4K4PRKCQ | |
| SCHEMBL23107367 | 0.76 | KIF18A (0.53) | PDE10APIK3CDHSD11B1MAP4K4PRKCQ | |
| SCHEMBL14138640 | 0.76 | GPR119 (0.68) | GPR119MAP4K4 | |
| SCHEMBL31052652 | 0.76 | CKS1B (0.60) | PDE10ACKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL31211262 | 0.76 | CCR5 (0.43) | CCR5GPR119PIK3CDHSD11B1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |