Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110351 | 0.86 | L3MBTL1 (0.58) | HRH4HTR3AL3MBTL1HTTATM | |
| SCHEMBL23110345 | 0.84 | RAB9A (0.58) | HRH4HTR3AMEN1NPC1RAB9A | |
| SCHEMBL23110068 | 0.82 | HTT (0.48) | HRH4HTR3AL3MBTL1HTTATM | |
| SCHEMBL23110346 | 0.81 | HRH4 (0.46) | HRH4HTR3AP2RX7MEN1NPC1 | |
| SCHEMBL23110349 | 0.80 | HTR3A (0.51) | HRH4HTR3AL3MBTL1HTTATM | |
| SCHEMBL23110347 | 0.79 | HRH3 (0.57) | HRH4HTR3AP2RX7MCHR1HRH3 | |
| SCHEMBL23110353 | 0.79 | L3MBTL1 (0.53) | HRH4HTR3AL3MBTL1HTTATM | |
| SCHEMBL23110431 | 0.78 | AR (0.50) | HTR3AL3MBTL1HTTATMP2RX7 | |
| SCHEMBL23110447 | 0.78 | AR (0.50) | HTR3AL3MBTL1HTTATMP2RX7 | |
| SCHEMBL23110352 | 0.78 | L3MBTL1 (0.52) | L3MBTL1HTTATMMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220315568-A1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. | 2022-10-06 | — | — | US | disclosed |
| WO-2021050913-A1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2021-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315568-A1 | INHIBITORS OF SARM1 | SARM1, SMN1; SMN2, SARNP | HRH4 4644/4885HTR3A 3781/4885L3MBTL1 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.