Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110690 | 0.85 | GPR119 (0.51) | GPR119NAMPTCCNCCDK8HASPIN | |
| SCHEMBL19030530 | 0.85 | GPR119 (0.43) | GPR119ALDH1A1LMNAMAPTHRH3 | |
| SCHEMBL23110785 | 0.82 | GPR119 (0.42) | GPR119ALDH1A1LMNAMAPTHRH3 | |
| SCHEMBL19030303 | 0.79 | MAPT (0.46) | GPR119ALDH1A1LMNAMAPTHRH3 | |
| SCHEMBL29634691 | 0.76 | GPR119 (0.54) | GPR119NAMPTCCNCCDK8HASPIN | |
| SCHEMBL22520476 | 0.76 | GPR119 (0.52) | GPR119NAMPTCCNCCDK8HASPIN | |
| SCHEMBL18572347 | 0.74 | CCNC (0.50) | GPR119NAMPTCCNCCDK8HASPIN | |
| SCHEMBL25343723 | 0.74 | GPR119 (0.49) | GPR119ALDH1A1HRH3 | |
| SCHEMBL24408939 | 0.73 | GPR119 (0.47) | GPR119NAMPTMAPTHRH3 | |
| SCHEMBL3494832 | 0.73 | KMT2A (0.54) | GPR119ALDH1A1LMNAMAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112480101-B | IRAK4 kinase inhibitor, preparation and application thereof | 中国科学院上海药物研究所 | 2022-11-25 | — | — | CN | disclosed |
| WO-2021047677-A1 | IRAK4 KINASE INHIBITOR AND PREPARATION THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2021-03-18 | — | — | WO | disclosed |
| CN-112480101-A | IRAK4 kinase inhibitor and preparation and application thereof | 中国科学院上海药物研究所 | 2021-03-12 | — | — | CN | disclosed |