Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.51 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110491 | 0.85 | GPR119 (0.49) | GPR119NAMPTUSP30HRH3CCNC | |
| SCHEMBL31235945 | 0.79 | NR1H2 (0.53) | GPR119NAMPTHRH3KMT2AHDAC1 | |
| SCHEMBL22520476 | 0.79 | GPR119 (0.52) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL31235967 | 0.79 | GPR119 (0.56) | GPR119NAMPTHRH3KMT2AHDAC1 | |
| SCHEMBL29634691 | 0.79 | GPR119 (0.54) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL19029978 | 0.78 | GPR119 (0.44) | GPR119HRH3 | |
| SCHEMBL29935368 | 0.78 | GPR119 (0.44) | GPR119HRH3 | |
| SCHEMBL25343723 | 0.76 | GPR119 (0.49) | GPR119HRH3KMT2A | |
| SCHEMBL24408939 | 0.76 | GPR119 (0.47) | GPR119NAMPTHRH3KMT2A | |
| SCHEMBL18572347 | 0.75 | CCNC (0.50) | GPR119NAMPTKMT2ACCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112480101-B | IRAK4 kinase inhibitor, preparation and application thereof | 中国科学院上海药物研究所 | 2022-11-25 | — | — | CN | disclosed |
| WO-2021047677-A1 | IRAK4 KINASE INHIBITOR AND PREPARATION THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2021-03-18 | — | — | WO | disclosed |