Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 7/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.40 |
| ▸ | GCGR | P47871 | 4/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | MATK | P42679 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110826 | 0.75 | PLAU (0.45) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL23093213 | 0.73 | PTGS2 (0.47) | PTGS1PTGS2 | |
| SCHEMBL29802404 | 0.73 | PTGS2 (0.47) | PTGS1PTGS2 | |
| SCHEMBL4212545 | 0.68 | MAOB (0.42) | PTGS2NISCHGAASMN1; SMN2MAPT | |
| SCHEMBL23093241 | 0.68 | ALDH1A3 (0.42) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL29802385 | 0.68 | ALDH1A3 (0.42) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL23110919 | 0.68 | CCR4 (0.35) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL23110513 | 0.66 | CCR4 (0.34) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL10995014 | 0.66 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL23111067 | 0.65 | PLAU (0.32) | MAPK13MAPK12MAPK11MAPK14GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050700-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2021-03-18 | — | — | WO | disclosed |