Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093304 | 0.80 | PTGS2 (0.49) | SYKMAOB | |
| SCHEMBL2588073 | 0.71 | NR4A2 (0.50) | KDM4EALDH1A1NR4A2MAPTNPC1 | |
| SCHEMBL6170224 | 0.68 | PIP4K2A (0.47) | KDM4EDHODHMAPTNPC1RAB9A | |
| SCHEMBL31329846 | 0.68 | NR4A2 (0.56) | SYKKDM4EALDH1A1NR4A2MAPT | |
| SCHEMBL30133446 | 0.68 | SYK (0.55) | SYKKDM4ENR4A2MAPTDYRK1B | |
| SCHEMBL26130603 | 0.68 | SYK (0.55) | SYKKDM4ENR4A2MAPTDYRK1B | |
| SCHEMBL6001719 | 0.68 | ABCB1 (0.50) | KDM4EALDH1A1DHODHMAPTKDM1A | |
| SCHEMBL30764354 | 0.68 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPTNPC1POLB | |
| SCHEMBL6001927 | 0.68 | MEN1 (0.55) | KDM4EALDH1A1MAPTPOLBKDM1A | |
| SCHEMBL2815340 | 0.68 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050700-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2021-03-18 | — | — | WO | disclosed |