SCHEMBL2311233

SCHEMBL2311233

NS(=O)(=O)c1cccc(NS(=O)(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)c1

nearest known ligand 0.62

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA2 P00918 12/20 0.62
CA1 P00915 11/20 0.62
FFAR4 Q5NUL3 1/20 0.57
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
ABL1 P00519 1/20 0.51
BCR P11274 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2237325 0.86 CA2 (0.47) CA2CA1MEN1KMT2AABL1
SCHEMBL28561814 0.84 FFAR4 (0.61) FFAR4MEN1KMT2A
SCHEMBL2235290 0.82 CA1 (0.73) CA2CA1MEN1KMT2A
SCHEMBL2304525 0.81 CA2 (0.64) CA2CA1FFAR4MEN1KMT2A
SCHEMBL28913958 0.81 KIF11 (0.69) FFAR4
SCHEMBL10093399 0.81 POLB (0.74) FFAR4MEN1KMT2A
SCHEMBL31681329 0.80 FFAR4 (0.65) FFAR4MEN1KMT2A
SCHEMBL26536748 0.80 HSD17B2 (0.62) FFAR4KMT2A
SCHEMBL14458175 0.80 ALOX15 (0.64) FFAR4MEN1KMT2A
SCHEMBL2235397 0.79 CA1 (0.69) CA2CA1FFAR4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2349990-A1 ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE Pimco 2664 Limited (GB) 2011-08-03 EP disclosed