Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23113422 | 0.81 | POLB (0.36) | OPRL1CAMK1DOPRM1OPRK1 | |
| SCHEMBL22497923 | 0.78 | NOTUM (0.40) | OPRL1OPRM1OPRK1OPRD1HDAC3 | |
| SCHEMBL18726215 | 0.77 | OPRL1 (0.43) | OPRL1OPRM1OPRK1OPRD1SLC6A4 | |
| SCHEMBL2269182 | 0.74 | TSHR (0.46) | TSHROPRL1OPRM1SLC6A4HDAC3 | |
| SCHEMBL23113569 | 0.74 | TSHR (0.35) | TSHRMAPK1NR2E1KDM1ASLC6A4 | |
| SCHEMBL130383 | 0.72 | TSHR (0.56) | TSHRMAPK1NR2E1 | |
| SCHEMBL394717 | 0.72 | TSHR (0.56) | TSHRMAPK1NR2E1 | |
| SCHEMBL31557722 | 0.72 | OPRL1 (0.62) | OPRL1OPRM1OPRK1OPRD1KDM1A | |
| SCHEMBL30697726 | 0.71 | OPRL1 (0.40) | OPRL1OPRM1OPRK1OPRD1SLC6A4 | |
| SCHEMBL26929228 | 0.71 | OPRL1 (0.40) | OPRL1OPRM1OPRK1OPRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530193-B2 | Kinase inhibitors | THE UNIVERSITY OF MANCHESTER (GB) | 2022-12-20 | — | — | US | disclosed |
| EP-3793996-A1 | KINASE INHIBITORS | The University of Manchester (GB) | 2021-03-24 | — | — | EP | disclosed |
| CN-112119077-A | Kinase inhibitors | 曼彻斯特大学 | 2020-12-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530193-B2 | Kinase inhibitors | CAMKK2, CAMK1, CAMKK1 | TSHR 3310/4885MAPK1 89/4885OPRL1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.