Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15695610 | 0.89 | KDM4E (0.65) | PHGDHKDM4EPKMAKR1C3HPGD | |
| SCHEMBL14733308 | 0.87 | KDM4E (0.62) | PHGDHKDM4EPKMAKR1C3HPGD | |
| SCHEMBL21930867 | 0.85 | KDM4E (0.71) | KDM4EHPGDF2HSD11B1SMN1; SMN2 | |
| SCHEMBL30380803 | 0.84 | KDM4E (0.74) | KDM4EHPGDF2HSP90AA1HSD11B1 | |
| SCHEMBL19097955 | 0.81 | PHGDH (0.59) | PHGDHKDM4EPKMAKR1C3HPGD | |
| SCHEMBL23113264 | 0.81 | HPGD (0.58) | PHGDHKDM4EPKMHPGDMAPT | |
| SCHEMBL11894194 | 0.79 | PHGDH (0.56) | PHGDHKDM4EPKMAKR1C3HPGD | |
| SCHEMBL1013250 | 0.78 | EPHX2 (0.52) | KDM4EAKR1C3HPGDHTTTSHR | |
| SCHEMBL31703347 | 0.78 | KDM4E (0.51) | PHGDHKDM4EPKMHPGDF2 | |
| SCHEMBL30584223 | 0.78 | EPHX2 (0.52) | KDM4EAKR1C3HPGDHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530193-B2 | Kinase inhibitors | THE UNIVERSITY OF MANCHESTER (GB) | 2022-12-20 | — | — | US | disclosed |
| EP-3793996-A1 | KINASE INHIBITORS | The University of Manchester (GB) | 2021-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530193-B2 | Kinase inhibitors | CAMKK2, CAMK1, CAMKK1 | PHGDH 939/4885KDM4E 1899/4885PKM 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.